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In ERO1B, the four Cys are retained in the NTR of fishes and sharks, but only two Cys, homologous to those forming the inner CSD, are present in ERO1B of amphibians and higher teleosts

It works through different central nervous system pathways and does not directly inhibit COX enzymes in the same way, making it a less disruptive choice for pain management in this context

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