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& Sahin, M

In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability

Consequently, it is crucial to design systematic experimental approaches to investigate how natural products influence thyroid disease and the associated physiological mechanisms

Statistical analysis was done using a two-tailed Students t-test