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Some studies suggest that their benefits and large-scale clinical trials have not consistently found positive effects, and excessive intake may even be harmful

Physiological application of methionine supplementation is dose-dependent, for instance, a low methionine diet suppresses the neurogenesis in animal models, whereas high dietary methionine has been associated with mild cognitive impairment primarily due to mitochondrial dysfunction (197)

We found that decreased NRF2 expression and activation resulted in increased oxidative stress in psoriatic lesional skin

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