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While one study reported that transplanting GM from aged mice into young, healthy mice led to a reduction in lean mass without affecting bone mass (151), another study demonstrated that transferring fecal matter from aged osteoporotic rats to younger ones induced GM dysbiosis and promoted OP ( Drugs and compounds Various drugs and compounds have demonstrated the ability to slow down the progression of OP by modulating the GM (152)

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Thus, FOXO4-DRI actually is most effective against senescent cells expressing high levels of SASP and could as such be particularly effective against loss of renal function

doi: 10.1126/science.329.5990.386