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J Drug Deliv Sci Technology (2025) 108:1069644

ALS is characterized by the progressive loss of motor neurons, leading to muscle weakness and paralysis

Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW: Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous