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Similarly, mutations in the ATP13A2 gene associated with PD result in widespread lysosomal impairment, characterized by membrane instability, impaired acidification, reduced processing of lysosomal enzymes, and diminished degradation of substrates and autophagosomes [118]

Notably, blocking lactate transport by inhibiting MCT1 or GPR81 promotes ferroptosis primarily through alterations in lipid metabolism rather than through conventional ferroptosis regulators, as evidenced by unchanged GPX4 and FSP1 levels (57)

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Start with reduced intensity, duration, and frequency compared to your pre-injury levels