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In randomized, controlled human studies, GHKCu applied topically has been shown to increase collagen and elastin production in aged skin, improve dermal thickness and hydration, and significantly reduce wrinkle volume and depthcompared with controls supporting its role in skin rejuvenation and antiaging research

A KaplanMeier survival curve was generated by correlating scores to PFS

Therefore, we envisaged the replacement of the naphthyl ring with the isosteric BCHep counterparts 50a c could suppress CYP1A-mediated oxidation of the naphthalene (Fig