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In controlled human dermal studies, 12-week topical application improved measurable collagen density in 70% of subjects

Samples were acquired on an Aurora 5 L Flow cytometer (Cytek Biosciences), unmixing and spillover correction were performed on SpectroFlo (Cytek Biosciences), conventional FCS gating and clustering were performed in Flowjo 10.8.1 with Phenograph and UMAP plugins

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In addition, the change of inflammatory factors often followed with oxidative stress and programmed cell death [85]