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This NAD+ elevation activates sirtuins (particularly SIRT1), enhances mitochondrial function, and preserves methylation capacity by reducing S-adenosylmethionine (SAM) consumption

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Activation of these receptors triggers two complementary processes: it accelerates lipolysis (the breakdown of stored triglycerides into free fatty acids for energy) while simultaneously inhibiting lipogenesis (the conversion of glucose and other substrates into new fat stores)