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CagriSema treatment resulted in substantially greater and clinically meaningful weight loss (-20.4%) than semaglutide alone (-14.9%), cagrilintide alone (-11.5%), or placebo (-3.0%), a finding consistent with at least partial additivity, although the study design does not permit a formal assessment of additive or synergistic effects

Rossi, M., Amaretti, A

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Yet Cohens book and various studies describe streaks as simply the randomness of a large data set and not being in any zone at all