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These risks highlight the need for individualized assessments before intervention, standardized dosing and duration, and long-term safety monitoring to ensure clinical applicability and minimize potential harms

Patented: see www.takeda.com/en-us/patents Revised: 3/2025 ADV372 ADVATE [Antihemophilic Factor (Recombinant)] (For intravenous use only) Do not attempt to do an infusion to yourself unless you have been taught how by your healthcare provider or hemophilia center

Szab D, Tod P, Glncsr F et al (2022) Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1 pathway