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Characterized Signaling Pathways Published research has identified multiple cellular and molecular interactions: Telomerase Activation (hTERT Upregulation) In-vitro studies in human fetal fibroblast cell lines demonstrated that Epitalon treatment increased telomerase activity and upregulated expression of the catalytic subunit hTERT, correlating with extended cellular replicative lifespan and attenuated telomere shortening across successive cell divisions (Khavinson et al., Bulletin of Experimental Biology and Medicine, 2003)