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Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, glucagon) that remains unlicensed in the UK, with no MHRA approval, no NHS availability, and no BNF listing as of 20242025

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Laboratory studies in photoaging models show that combined peptide approaches addressing multiple regenerative pathways produce superior outcomes compared to single-agent interventions, with improvements in collagen organization, elastin fiber quality, hyaluronic acid content, and overall dermal architecture