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Sun N, Tian Y, Chen Y, Guo W, Li C

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As for vascular growth, which is highly correlated with tumor development, bilirubin inhibits ERK activity in damaged blood vessels, and because ERK activation is associated with the mitogenic stimulation-induced cyclin D1 expression (102, 103), the reduction of ERK activity caused by bilirubin may be responsible for the down-regulation of cyclinD1 by bilirubin after arterial injury

(1) Healing in different tissues In addition, the other point considers the stomach cytoprotection concept wound healing concept.1Note, the original cytoprotective agenda (with the generalized cell protection, within the same cytoprotective background) includes the improved healing in different tissues