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As is known, ROS plays a major role in atorvastatin induced oxidative stress ( Furthermore, mitochondrial dysfunction, in particular impaired function of the electron transport chain, is frequently associated with in statin-associated skeletal muscle damage ( GPx4 is the most critical ferroptosis defense gene that encodes cytosolic, mitochondrial, and nucleolar isoforms (Figure 10

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GHK-Cu differs from other signal peptides (Matrixyl, acetyl hexapeptide-8, palmitoyl tripeptides) in its copper-coordinated mechanism and broad gene-expression effects