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Pathways impacted include tumor necrosis factor-alpha (TNF), TP53, NF-kB , and more in the pathways involving apoptosis, oxidative stress, and cell death.[ref] Several studies have shown that glyphosate increases TNF-alpha , which is an inflammatory cytokine.[ref][ref] An animal study found that exposure to glyphosate infiltrated the brain and elevated TNF levels both in the brain and in the plasma.[ref] In the intestines, glyphosate has been shown in animals to increase Nrf2 levels, inducing NF-kB.[ref] Nuclear factor-B (NF-B) signals for danger and induces an innate immune response