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According to the latest EASL Clinical Practice Guidelines, non-invasive scores, serum markers, liver stiffness and imaging methods should be used for ruling out rather than diagnosing advanced fibrosis in low-prevalence populations and should be preferentially employed in patients at risk of advanced liver fibrosis (63)

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plantarum activates toll-like receptors (TLRs) signaling, leading to the translocation of the pivotal structural protein Zonula occludens-1 (ZO-1) to the tight junction domain in intestinal models (165)