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As hair keratinocytes are also major sources of -catenin, we also verified the increased expression levels of CTNNB1 , CCND1, LEF1 , and TCF4 in mechanically isolated DPs (Supplementary Figure 5)

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2.8 In vivo evaluation of MitoQ and DPI: tolerability and limited efficacy in NB mouse models Finally, to evaluate the efficacy of MitoQ and DPI in vivo , both drugs were administered individually and in combination to Th- MYCN transgenic NB mice