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To reduce reactions: Allow the solution to warm to room temperature for 5 to 10 minutes before injecting (cold solution stings more) Inject slowly over 5 to 10 seconds rather than pushing the plunger quickly Apply gentle pressure with a cotton ball after withdrawing the needle (do not rub) Consider using a higher concentration to reduce injection volume If injection site reactions persist , switching to a different anatomical site or adjusting your reconstitution concentration may help

68 And, a first-in-human open-label interventional study in 10 neonates showed that intranasal delivery of bone marrow-derived MSCs was safe and had no adverse side effects

This is a key variable to consider in experimental design

The NHS advises that taking up to 2mg (2000 micrograms) daily of vitamin B12 supplements is unlikely to cause harm, with no established upper limit in the UK