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In patients with active RA, the addition of low-dose sirolimus (0.5 mg every other day for 24 weeks) to conventional immunosuppressive therapy effectively increased Treg cell frequencies, reduced Th17 cell populations, and improved clinical disease activity (Chictr.org.cn identifier: ChiCTR-IPR-17010307) (240)

Medications: Certain medications have the unfortunate side-effect of significantly suppressing gut motility, which can lead to bacteria hanging around in the small intestine

As part of a provider-guided approach, Semaglutide may be explored by individuals focused on long-term lifestyle goals and overall wellness support