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Senescent cells are cells that have permanently halted their cell cycle ('replicative arrest') but resist apoptosissometimes called 'zombie cells.' They accumulate with age in multiple tissues and secrete a pro-inflammatory cocktail called the Senescence-Associated Secretory Phenotype (SASP), containing IL-6, IL-8, MMP-3, MMP-9, TNF-, and other factors that damage surrounding healthy tissue

doi: 10.3389/fcell.2020.00055 Received 26 October 2019 Accepted 22 January 2020 Published 07 February 2020 Volume 8 - 2020 Edited by Albena Todorova Dinkova-Kostova, University of Dundee, United Kingdom Reviewed by Wei-Hsiung Yang, Mercer University, United States

As interest in multi-peptide repair protocols continues to grow, blended formulations like this one are likely to see increasing adoption in the research community.

Ongoing clinical trials test the efficiency of immune system-activating monoclonal antibodies Ipilimumab and Pembrolizumab in melanoma treatment [2, 8, 9]