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In preclinical treatment models, the HDACi have exhibited neuroprotective effects and stimulation of neurogenesis in traumatic brain injury and ischemia (Kim et al., 2009), restoration of memory and learning in traumatic brain injury in neurodegenerative mice (Vecsey et al., 2007) and exerted antidepressant-like effects (Schroeder et al., 2007)

This review provides an in-depth analysis of several agents, including VEGF, angiostatin, axitinib, everolimus, bevacizumab, semaxinib, and ranibizumab, shedding light on their usefulness in the treatment of neurodegenerative diseases