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the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor

Some people might suggest that the lung cancer findings discussed above could be explained by the cyanide in cyanocobalamin rather than by B12 itself

Those with diseases that affect the gut, such as Crohns disease or celiac disease, are also at risk ( Summary Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet

The conditions most commonly associated with unexplained hypercobalaminemia include: Liver disease