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When enough charged ions cross the channels, other electricity-dependent ion channels start rapidly opening, letting in a rush of charged particles and causing the whole cell to fire. At the distant end of the neuron, chemical neurotransmitters are released, and the signal can move to other cells

Jaccard G, Tafin Djoko D, Korneliou A, and Belushkin M

Ultimately, it comes down to personal preference

But you also dont want to let them off the hook with just one cigarette a day since that causes many problems. As for the benefits of quitting completely, Hackshaw noted that such a strategy can even help reverse much of the damage caused by decades of smoking within just a few years