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Given the many unknowns with high dose folic acid supplementation, particularly unmetabolized folic acid (as covered in my folate article), Im not able to draw any strong conclusions here

Abstract In recent years, the increasing number of infertility cases has led to a greater research focus on the reproductive toxicity of drugs due to the fact that some classes of pharmacotherapeutic agents have been found to exert deleterious effects on the reproductive system

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Similarly, the Reducing Deaths due to Oxidative Stress trial (REDOX), a randomized, blinded trial involving 1,223 patients with multi-organ failure across 40 ICUs in Canada, the United States, and Europe, found that glutamine supplementation was associated with increased mortality without other clinical benefits