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Conclusions Although many points remain to be further shown or explained, particularly due to the use of the animal models and their general translational significance, this review attempts to resolve the shortage that the pleiotropic beneficial effects of BPC 157 may not fulfill the general standard neurotransmitter criteria, in classic terms

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BPC-157 operates primarily at the local tissue level: it upregulates VEGF and EGF expression at the injury site, modulates the nitric oxide system to improve blood flow to damaged tissue, and directly promotes fibroblast migration and collagen organization through the FAK-paxillin pathway