Symptoms accompanying atopic dermatitis include itching, swelling, eczema, dryness, redness of the skin, and the formation of lichen
4.1 Revisiting classical pathways: context-dependent roles of Nrf2 and HDAC inhibition SFN activates the Nrf2 pathway through covalent modification of specific cysteine residues (Cys151, Cys273, and Cys288) on the Keap1 protein, leading to Nrf2 stabilization, nuclear translocation, and transcriptional activation of cytoprotective genes including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione biosynthesis enzymes (63)
Neurobiol Dis 23(1):7786
Pro-inflammatory M1 macrophages accumulating in thyroid tissue secrete hepcidin and ferritin, altering iron homeostasis and increasing oxidative stress, which in turn promotes thyroid follicular cell ferroptosis (25)