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For polyphenols to achieve meaningful clinical impact in PsO, future efforts must focus on standardized extraction protocols, AI-driven formulation optimization, large-scale manufacturing strategies, and rigorous comparative trials against benchmark biologics and small molecules

On top of lost efficacy observed with oxidized nebulized GSH, it can actively increase airway irritation

410.3389/fpls.2013.00199 Cobbett CS, May MJ, Howden R, Rolls B (1998) The glutathione-deficient, cadmium-sensitive mutant, cad2-1, of Arabidopsis thaliana is deficient in glutamylcysteine synthetase

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