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For example, the conversion of morphine into morphine 6-glucuronide

Due to the central role that GSH appears to play in COVID-19, we hypothesized that supplementing endogenous glutathione with L-GSH would interrupt this cycle, which could be evidenced by decreased levels of the previously mentioned cytokines due to reduced ROS

Another crucial point is that, when an individuals antioxidant defense system is weak or saturated, inhaling additional ROS or other reactive metabolites produced by the biotransformation of chemicals in tobacco smoke can increase the amount of oxidative stress caused by the gas-phase and tar-phase derived ROS (60)