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The model is the lateral line of zebrafish larvae, whose hair cells are homologous to those of the human inner ear

Additionally, pirin (PRI), an iron-binding nuclear protein, plays a critical role in nuclear stress during ferroptosis by downregulating ACSL4 mRNA and its product, AA, thereby inhibiting ACSL4-mediated ferroptosis in PDAC [44]

Currently, the preclinical development of these strategies appears more challenging to avoid strong side effects, but the expected results are commensurate with patients hopes for treatments