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Biochem Pharmacol 62 : 787794 Rahman I, Yang SR, Biswas SK 2006 Current concepts of redox signaling in the lungs

Oxidants, antioxidants and the pathogenesis of emphysema

Furthermore, increased ACE2 expression in alveolar type II pneumocytes and alveolar macrophages of individuals with severe SARS-CoV-2 disease (ARDS with diffuse alveolar damage) requiring mechanical ventilation (Baker et al., 2021) favors a concomitant increase in oxidative stress in those individuals

P53, a tumor suppressor protein, is a critical regulator in various cell biological processes, mainly including cell cycle arrest and apoptosis, which is closely associated with AKI progression (Tang et al., 2019)