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ICH Q2(R2), for example, describes validation concepts for analytical procedures and includes principles such as specificity, accuracy, precision, and suitable reference materials in analytical validation contexts [2]

While traditionally viewed as a stable lineage committed to immunosuppression, emerging evidence indicates that certain Treg subsets can acquire effector-like characteristics under inflammatory conditions, including the production of pro-inflammatory cytokines

We recommend following up these patients closely to develop better recommendations for management based on long-term outcome data for example by cardiovascular screening every 25 years and assessments of quality of life by questionnaires

This analysis consisted of 430,414 participants from UK Biobank who were followed from recruitment (2006-2010) to 2021