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Epidermal melanocytes, owing to their specialized role in melanin synthesis, exhibit a heightened susceptibility to elevated ROS production, a phenomenon accentuated by solar exposure during the tanning process and instances of inflammation, subsequently culminating in post-inflammatory hyperpigmentation 17

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Importantly, this anti-inflammatory action does not suppress immune function entirely like corticosteroids often do

Notably, we also observed a marked reduction in KLRG1 expression following melatonin treatment