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The knock-in was additionally validated by Sanger sequencing and Synthego analysis tool ( analysis with the following Primers: amplification: CCGACTGGTGCATCTCCTTT and GAGAGCCTGTAATGCTAGGCAG sequencing: GAGAGCCTGTAATGCTAGGCAG

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Meta-analyses of randomized controlled trials suggest that infusion of 300 to 600 mg/day of lipoic acid for two to four weeks significantly reduced the symptoms of diabetic neuropathy to a clinically meaningful degree (55, 74)

It is worth noting that the energy-intensive aspect of melanogenesis suggests a high demand for adenosine triphosphate