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To assess the metabolic changes induced by bTNF- in bFLS, we performed a metabolic flux analysis by using d-glucose- 13 C 6 , which generates citrate containing two heavy-labeled carbons (M + 2-labeled citrate) following oxidative decarboxylation of glucose-derived pyruvate

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Furthermore, SOD1 undergoes the cyclic reduction and oxidation of copper ions (Mccord and Fridovich, 1969), and it also inhibits oxidative inactivation of nitric oxide to prevent peroxynitrite formation (Harraz et al., 2008)

It is particularly effective when taken alongside Vitamin C, as these two antioxidants work together to neutralize free radicals and recycle one another