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Vaginally applied estradiol or estriol is effective for genitourinary symptoms specifically, though estriol is not available as an FDA-approved product but is approved by regulatory agencies in other countries

Particular attention has focused on citrus fruits, dark-green vegetables and cruciferous vegetables that have been shown to influence various stages in the development of cancer ( 5 ) by preventing the genotoxic damage of cellular DNA upon exposure to endogenous or exogenous carcinogens (initiation phase), inhibition of clonal expansion of initiated cells by induction of apoptosis and modulation of signal transduction (promotion phase) and blockade of tumour with invasive and metastatic potential (progression phase)

Khojasteh-Bakht, S

In addition, on the peripheral blood smear, macrocytes and hypersegmented polymorphonuclear leukocytes may be seen