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Safety was assessed
Relevant to the studies presented here, at one-month of age -synuclein transgenic mice (SWT+/+) exhibit increased numbers of activated microglia in the SNpc as well as increased expression of TNF in the SN and striatum, demonstrating an early microglial activation driven by the overexpression of -synuclein (Su et al
1 H NMR (400 MHz, Chloroform-d) = 9.30 (d, J = 5.7 Hz, 1H), 8.50 (d, J = 7.9 Hz, 1H), 8.21 8.07 (m, 3H), 7.69 (t, J = 6.8 Hz, 1H), 7.09 (dd, J = 9.3, 4.7 Hz, 2H), 6.17 (d, J = 6.3 Hz, 1H), 5.85 (dd, J = 15.4, 6.5 Hz, 2H), 5.69 (d, J = 6.3 Hz, 1H), 4.37 4.28 (m, 2H), 3.92 (s, 2H), 2.50 (s, 3H), 2.33 2.21 (m, 1H), 2.14 (p, J = 6.1 Hz, 2H), 1.08 (d, J = 6.9 Hz, 3H), 0.99 (d, J = 6.9 Hz, 3H)
Results A total of 3417 participants underwent randomization, with 2108 assigned to receive cagrilintidesemaglutide, 302 to receive semaglutide, 302 to receive cagrilintide, and 705 to receive placebo
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