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(2) The male steady state is slightly different than in [11] , so we adjust the steady states of S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and Bet, which occur in the velocity equation for CBS and the velocity equation for betaine-homocysteine methyltransferase (BHMT)

While large-scale human trials are still developing, a small pilot study with 16 patients experiencing knee pain showed promising pain relief with no adverse effects

This review synthesizes evidence from peer-reviewed studies published between 2020 and 2026, focusing on mechanisms, efficacy, and safety

LL, JH, and QM contributed equally to this work