& Samulski, R
Selenium toxicity (selenosis) can occur with chronic excessive intake and may cause: Gastrointestinal disturbances (nausea, diarrhoea) Hair loss and brittle nails Skin rashes and lesions Neurological symptoms (peripheral neuropathy, fatigue, irritability) Garlic-like breath odour In severe cases, liver and kidney damage Safe consumption guidelines: Limit intake to one to two Brazil nuts per day to obtain selenium benefits whilst avoiding toxicity risk Avoid consuming Brazil nuts daily if taking selenium supplements Be aware that selenium content varies significantly between nuts Consider overall dietary selenium intake from other sources (fish, meat, eggs, cereals) Seek medical advice if you experience symptoms that might suggest selenosis Additional considerations: Brazil nuts are calorie-dense and may contribute to weight gain if consumed in large quantities
[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Hornsby AK, Redhead YT, Rees DJ, Ratcliff MS, Reichenbach A, Wells T, Francis L, Amstalden K, Andrews ZB, and Davies JS
The downstream effects of RAGE-induced ROS in rat mesangial cells include reduced levels of the antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) (50) and increased activation of phosphoinositide 3-kinase (PI3K)/AKT pathway, which leads to activation of nuclear factor (NF)-B and the production of pro-inflammatory cytokines (51)
