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In particular, to recapitulate the proliferative phase, organoids are exposed to an estrogen receptor (ER) agonist (typically E2), while a combination of E2 with a progesterone receptor (PGR) agonist (typically P4 or medroxyprogesterone acetate (MPA)) and decidualization-promoting cyclic adenosine monophosphate (cAMP) is employed to replicate the transition to the secretory phase [53, 54, 63]

& Crotty, M

10.1016/S0140-6736(14)61393-3 92 Kalinowska-yszczarzA.SzczuciskiA.PawlakM

This mechanism facilitates the controlled release of various therapeutic agents, including chemotherapeutics, photosensitizers, sonosensitizers, peptides, proteins, and nucleic acids