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Taken together, these observations suggest that except in vitamin B 12 deficiency (which only responds to cyanocobalamin treatment because of the inactivation of methionine synthase), folate treatment should be the most adequate therapy to reverse hyperhomocysteinemia detected both under basal conditions and after an oral methionine load

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Secondary structural elements included -helices (labeled H1, H2, etc., depicted as purple cylinders), -sheets (strands labeled A, B, etc., shown as purple arrows), and conformational motifs (-turns, -turns, and -hairpins)