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Research published in studies examining synaptic density following Dihexa administration found elevated synaptophysin and PSD-95 expressionmarkers of presynaptic and postsynaptic densitysustained for 714 days after a single administration cycle

Together, these findings provide compelling evidence that oxidative stress plays a critical role in the pathophysiology of depression and may represent both a biomarker of disease severity and a potential target for therapeutic intervention through modulation of antioxidant defenses (3537)

PMCID: PMC3277671

In type 2 diabetes and related states, this switch is broken: glucagon stays inappropriately high after meals, and the liver keeps producing glucose it does not need, worsening the postprandial spike