Excessive intracellular levels of iron ions generate hydroxyl radicals through the Fenton reaction interacting with hydrogen peroxide, thus promoting the production of reactive oxygen species (ROS), which cause lipid peroxidation and are believed to be the primary driver of ferroptotic cell death (Su et al., 2019), and this peroxidative damage can be further exacerbated by reductions in the activity of glutathione peroxidase 4 (GPX4) and glutathione (GSH) together with enhanced malondialdehyde (MDA) activity (Conrad and Sato, 2012
Ferroptosis, the programmed cell death due to iron and lipid dependent peroxidation, is associated with ageusia and anosmia, the early clinical manifestations of COVID-19 197,599,600
After a traditional lunch, we will go into the jungle, taking an ethno botanical walk along the tambopata trails, learning about the medicinal plants and trees of the region, and observing the impressive Amazonian ecosystem, where we can see walking palm trees, the Lupuna Museums, snakes, etc
While the lens is presumably able to source vitamin C and/or DHA from vitreous humor (Figure 5), it is unknown whether SVCT2 and GLUT1 are expressed at the posterior surface of the lens in order to facilitate this
