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Centers for Disease Control and Prevention (US)

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The Cannabinoid Studies Rather than the cannabis plant, most studies on seizures have looked at the effect of the two predominant cannabinoids: Delta-9-tetrahydrocannabinol (THC), the principal psychoactive component, which causes the euphoric high of the weed Cannabidiol (CBD), which has no psychoactive effect According to a review on alcohol, marijuana, and seizures published in 2001 in the journal Epilepsia, animal studies that look at the effect of THC and CBD on seizure activity show conflicting results and depend on the animal model, the cannabinoid, and the dose used: One experiment reported in Neuropharmacology found a single dose of THC facilitated electrically-provoked seizures in a mouse model