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10.1016/0014-5793(89)80547-2 239 HarveyS

Peter Lurie, a former FDA official who now leads the Center for Science in the Public Interest

While steady progress has been made in the understanding of NAFL/NASH pathophysiology and identification of therapeutic targets, relatively slow progress was achieved in the treatment of all aspects of NAFL/NASH even after years of intense research, 5,13,45 although several approved drugs for treating metabolic-related disorders and diseases showed promising outcomes in patients with NAFL/NASH, including Orlistat 46 used for the treatment of obesity (Fig