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First-in-human phase I study of the oral inhibitor of indoleamine 2,3-dioxygenase-1 epacadostat (INCB024360) in patients with advanced solid Malignancies

After the lung extracts were centrifuged (12,000 g , 10 min at 4C), the supernatant was collected, and protein concentrations were determined using a Bicinchoninic Acid (BCA) Protein Assay Kit (Beyotime Institute of Biotechnology)

MgIG also downregulates the mRNA expression of TLR2, TLR4, and NF-B in the liver, thereby reducing the production of pro-inflammatory cytokines (e.g., TNF-, IL-6) and alleviating liver tissue inflammation and oxidative stress ( DG primarily alleviates amphotericin B-induced liver injury through dual mechanisms involving inhibition of oxidative stress and apoptosis (Zhao et al., 2022)

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Zyrek A., Cichon C., Helms S., Enders C., Sonnenborn U., Schmidt M