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Key differentiators included APOE 4 in CE, elevated CRP and MMP9 in LAA, reduced miR-124/miR-21 in CE, deep white matter lesions in SVO, and cortical lesions with elevated D-dimer in LAA

Retatrutide activates three hormone receptors: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors

Varney, who has worked in obesity medicine for 16 years, explained that FDA-approved weight loss medications such as Ozempic and Wegovy are synthetic drugs designed to mimic naturally occurring peptides in the body, including insulin and glucagon-like peptide-1, or GLP-1