The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39
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Using an LPS-free, endotoxin-free peptide helps reduce confounding variables in growth-factor signaling, receptor-binding, and metabolic pathway studies, allowing observed effects to be attributed more accurately to IGF-1 LR3 activity rather than contaminants