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M3 receptors are primarily responsible for the normal contraction of the urinary bladder, although M2 receptors are also present, and my act to oppose sympathetically mediated smooth muscle relaxation mediated by beta-3 receptors (Andersson & Arner, 2004)

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GHK-Cu has the broadest base, with several decades of dermal, scalp and cosmetic-research publications, and a reasonable foundation in connective-tissue biology