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Two meta-analyses suggested that pioglitazone reverses or delays the progression of fibrosis, including advanced-stage fibrosis, which is an independent predictor of liver-related adverse events and mortality in MASLD/MASH patients
Differential gene expression analysis revealed a continuous trajectory of transcriptional changes with stage of disease progression from MASLD to advanced MASH (Supplemental Figure 7, A and B), indicating substantial transcriptional remodeling during MASLD/MASH progression
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